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Monitor Closely (1)pentobarbital will minimize the level or outcome of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to your decrease in fentanyl plasma concentrations, insufficient efficacy or, possibly, improvement of a w